Doctor Octopus

Otto Octavius, later called Doctor Octopus, is the main antagonist of Spider-Man 2 and will return in some capacity in the upcoming Marvel Cinematic Universe film Spider-Man: No Way Home.

He was a scientist who became possessed by his malevolent mechanical arms after an experiment with his fusion reactor funded by Harry Osborn went horribly wrong. From there, Otto turned into a dangerous super villain and the former second archenemy of Spider-Man.

He was portrayed by Alfred Molina.